Global Development Research Articles

Simultaneous Global Drug Development and Multiregional Clinical Trials (MRCT): 5 Years After Implementation of ICH E17 Guidelines.

The ICH E17 guidelines (2014-2017) on Multiregional Clinical Trials (MRCT) was a joint effort by the regulators and industry to facilitate simultaneous global drug development and registration through taking a strategic approach for clinical trials. In other words, the objective was to reduce the time it takes to bringing medications to patients around the world through minimizing unnecessary duplication of local or regional studies, which may add the regulatory burden to cost and time of bringing new therapies to patients. Under the auspices of ICH, training materials were created and provided to various stakeholders. Despite the successful promotion of the benefits of ICH E17 MRCT guidelines across the different regions, the uptake of some concepts (e.g., pooling strategy) in the ICH E17 guidelines has been slow. This paper describes various factors which could affect the conduct of MRCT at a global level, including ambiguity in definition of "region" (in MRCT), new regulatory requirements to enroll a diverse patient population, the use of decentralized clinical trials, use of data sources other than randomized clinical trials (e.g., use of Real Word Data), and the impact of the COVID-19 pandemic on the conduct of MRCT.

Gender Role Dynamics in Economic Development: Challenges and Opportunities for Women's Empowerment

The role of gender in economic development has become a major concern in the context of women's empowerment. This article investigates those dynamics with a focus on the challenges and opportunities faced in women's economic empowerment efforts. Through a comprehensive review of the literature, we explore the role of gender in economic development, explain the various challenges women face in access and control of economic resources, and identify opportunities to increase their empowerment. We also discuss the impact of gender roles in the context of global and regional economic development.

Non-functional demand model vs functional demand model: prospects for competitiveness in a transforming world

The purpose of the article is to analyse the problem of changing the relationship between non-functional and functional demand. The main task of the presented research is to define the most competitive model (based on functional or non-functional demand) of consumer behaviour in the conditions of the economy of the 20s of the XXI century. To solve this problem, we studied the structure of consumer demand: functional and non-functional ones. We identified the features of non-functional demand, and considered the reasons for its expansion in modern society. Moreover, paper highlights fixing changes in consumer orientations, which resulted in the search for satisfaction not only of material needs, but also aesthetic, emotional, and social ones. It allowed us to formulate a conclusion on the existence of objective reasons for the spread of non-functional demand. Within the framework of non-functional demand, we perform an analysis of origin and expansion of the downshifting phenomenon through the transformation of the basis of functional demand. The authors believe that qualitative changes in global socio-economic development have revolutionized the theoretical concepts of rationality, which are the basis of the functional demand model. Nevertheless, authors criticise the interpretation of downshifting as a model of irrational consumer behaviour, and put forward a hypothesis on the legitimacy of this new phenomenon to be analysed within the framework of functional demand. The authors consider the assumption of the possibility of changing the objectives of society to be a condition for the realization of this hypothesis. it can cause the transformation of «efficiency» concept over the past 300 years. Paper forecasts increasing of non-economic goals rationality, cooperation, mutual benefits, and the coupling of knowledge and technology to moral, cultural, and ethical principles and norms. As a result, in the contrary to the widespread assessment of downshifting as a deviant form of consumer behavior, there was put forward hypothesis considering downshifting as a part of classical consumer choice matrix, taking into account the transformation of this matrix itself.

Colonial erasures in gender and climate change solutions

AbstractDespite deliberate moves to integrate gender with climate change solutions, efforts do not go far enough to account for coloniality, thus falling short of achieving feminist, just and transformative ends. Coloniality is a political blind spot and a systematic amnesia in climate policies and actions, despite being a key driver of climate change manifested through various forms of extractivism, economic growth, and hegemonic Eurocentric knowledge production. As a corrective and a pathway toward realizing a post/decolonial feminist climate praxis, I will disclose the colonial underpinnings in (i) a persistent gender binary and women‐centered approaches; (ii) white feminist epistemic privileging; and (iii) acquiescing to masculine Enlightenment‐inspired techno‐managerialism. Furthermore, disclosures of colonial erasures entail a foundational re‐evaluation of the climate change narrative from an isolated form of natural crisis to a phenomenon embedded in complex histories of colonialism, extractivism, and capitalist exploitation that threatens the intrinsic interdependence of nature and society and planetary survival. As a result, a post/decolonial feminist climate praxis then asks that we foster and restore this interdependence by institutionalizing an ethics of socioecological care, acknowledging epistemic diversity through embodied knowledge, and carrying out intersectional justice.This article is categorized under: Climate, Nature, and Ethics > Climate Change and Global Justice Climate and Development > Sustainability and Human Well‐Being Climate and Development > Social Justice and the Politics of Development

Economic Development Pattern and Trade Imbalance: Comparing the U.S. with East Asia

With the development of trade globalization, East Asian countries have occupied an important position in global trade. The rise of the East Asian economy has led to a long-term trade deficit between the United States and East Asian countries, causing economic imbalance. Focusing on the economic development patterns of the United States and East Asian countries, this paper proposes a research question: How does the difference in economic development between the U.S. and East Asian countries lead to trade imbalance? This article uses comparative advantage and absolute advantage theory, Keynesian political economy, global savings glut hypothesis and the flying-geese model to provide theoretical support for the research, and then uses data from the World Bank and Bureau of Economic Analysis to further demonstrate. The last part of this paper makes an empirical analysis through case analysis and model tests. This study argues that differences in economic development lead to an international division of labor and a savings-investment gap, which in turn lead to trade imbalances.

Unveiling the Dynamics of Cryptosporidium in Urban Surface Water: A Quantitative Microbial Risk Assessment and Insights into Climatic and Seasonal Influences

In response to global urbanization and economic development, urban surface water pollution has become a universal challenge and particularly affects densely populated megacities, and Dhaka is no exception. The discharge of 98% of untreated domestic sewage and massive volumes of industrial wastewater from over 7000 industries escalate surface water crises. This study investigates microbial and fecal contamination with particular emphasis on Cryptosporidium in surface water, known for causing waterborne diseases, such as cryptosporidiosis. Findings reveal high Cryptosporidium oocyst concentrations and fecal contamination in various water bodies in Dhaka City. Among the investigated water bodies, the Buriganga River exhibits the highest Cryptosporidium oocyst concentration (46%), while the Balu River, Turag River, Shitalakkhya River, Dhanmondi Lake, Gulshan Lake, Banani Lake, Ramna Lake, and Crescent Lake also present high levels of oocyst concentrations ranging from 21–40%. This study also calculated infection risks and found that the infection risk of swimming is highest during the wet season and is (3.9 ± 2.2 (95% CI: 3.0–5.0)) × 10−2 per swimming event, whereas it is approximately (2.4 ± 1.9 (95% CI: 1.6–3.3)) × 10−2 during the dry season. Annual diving risks are approximately (1.2 ± 0.6 (95% CI: 0.9–1.4)) × 10−2, indicating considerably high risks. Most of the sampling sites generally show significantly higher risks than other study areas like the Mymensingh and Kushtia Districts. In light of these results, we strongly recommend immediate measures to address water quality issues and mitigate the risks associated with Cryptosporidium contamination in Dhaka’s surface water.

Research on coupling optimization of carbon emissions and carbon leakage in international construction projects

Due to the rapid economic development of globalization and the intensification of economic and trade exchanges, cross-international and regional carbon emissions have become increasingly severe. Governments worldwide establish laws and regulations to protect their countries' environmental impact. Therefore, selecting robustness evaluation models and metrics is an urgent research topic. This article proves the reliability and scientific of the assessment data through literature coupling evaluation, multidisciplinary coupling mathematical model and international engineering case analysis. The innovation of this project's research lies in the comprehensive analysis of the complex coupling effects of various discrete data and uncertainty indicators on the research model across international projects and how to model and evaluate interactive effects accurately. This article provides scientific measurement standards and data support for governments worldwide to formulate carbon tariffs and carbon emission policies. Case analysis data shows that the carbon emission ratio of exporting and importing countries is 0.577:100; the carbon trading quota ratio is 32.50:100.

The global development of value orientations, political support and democracy since the 1990s

This article analyzes the global development of democracy since the 1990s. The theoretical introduction is followed by a descriptive analysis of several indices of political support based on survey results for 89 countries that participated at least twice in the World Values Survey (WVS) or the European Values Study (EVS). The analysis focuses on emancipative value orientations measured by Welzel's Choice Index and several indicators of political support. The scores of these indicators are broken down by five regime types and seven world regions. The results confirm that the global decline of democratic quality since the mid-2000s has not been as dramatic as the pessimistic analyses of Freedom House and the V-Dem project have claimed. It has primarily taken place in a limited number of populous countries on which these publications have focused. When countries are treated equally, the quality of democracy has remained remarkably stable since the early 1990s. Emancipative values are globally on the rise, but their increase has been considerably higher in the established democracies. This supports the skeptical argument that they cannot be considered as the major cause of the third wave of democratization. The descriptive analysis is complemented by regression analyses for confidence in regime institutions and support for democracy as dependent variables. The evaluation of democratic regime performance is the strongest predictor of confidence in regime institutions. An intrinsic conception of democracy and the importance assigned to living in a democracy have the strongest influence on support for democracy. Emancipative value orientations have a minor influence on political support even in consolidated democracies. Finally, the analysis does not confirm the suspected relationship between the different levels of political support. Easton's theory of political support assumed that they mutually influence each other via a generalization of experiences or an overflow of values. Instead, it seems that confidence in regime institutions and support for democracy follow different cognitive logics.

Assessing ecopreneurship impact on composite sustainability in the food and beverage industry: A holistic AHP approach integrating economic and environmental dimensions.

The implementation of ecopreneurship is evolving to address environmental sustainability challenges posed by industrial pollution. Scholars are exploring ways to enhance ecopreneurship implementation globally. However, there's a gap in understanding how ecopreneurship affects sustainability across economic and environmental dimensions. This study aims to explore the impact of ecopreneurship on sustainability, considering both economic and environmental indicators. The investigation was conducted through Analytical Hierarchical Process (AHP) methodology covering 102 ecopreneurs operating in the Tanzania food and beverage industry. The results of the study showed that implementation of ecopreneurship results in the attainment of sustainability through composite scores of 79.5%. In conclusion, this study underscores the significant impact of ecopreneurship implementation on composite sustainability, as evidenced by notable reductions in environmental emissions and improvements in economic performance within the studied industries. The findings highlight the importance of integrating environmental considerations into entrepreneurial endeavors for achieving sustainability goals. It is recommended that stakeholders actively promote and incentivize the adoption of ecopreneurship practices, invest in eco-friendly technologies, foster collaboration, implement effective monitoring mechanisms, and integrate sustainability into business strategies. The study recommends stakeholders' efforts directed towards enhancing the implementation of ecopreneurship practices in line with the United Nations Sustainable Development Goals (SDGs, 2015–2030), specifically goal nine (9) on pollution prevention through the implementation of Eco practices-based solutions to foster innovations and sustainable industrialization. Thus, strategizing the implementation of ecopreneurship practices is considered to have an essential contribution to addressing the challenges of sustainability and therefore enriching the realization of the global sustainable development agenda.

Financial Reporting, Criminal-Juridical Protection, And Corruption in Albania

Purpose: The purpose of this paper is role of financial reporting and the accounting profession in the identification of corruption what is foreseen in the Criminal Code of the Republic of Albania regarding the activity of businesses that violate financial reporting in accordance with accounting standards, how they stand against each other with the aim of a true and fair view of the activities of each entity. Methods: This paper comes as an empirical study of the regulatory framework in Albania in the field of financial reporting and criminal-juridical protection provided in under Criminal Code of the Republic of Albania, as two influential indicators in the wide discussed phenomenon of corruption in our country. The study employs a combination of qualitative and quantitative methodologies. Through empirical and statistical analysis, the actuality in Albania will be understood in the trinomial of financial reporting, criminal-juridical protection, and corruption. At the end, suggestions for the main actors will be presented for the role of financial reporting in the fight against corruption and organized crime, identifying it as a main tool. Results and Discussion: Corruption and organized crime are increasingly finding themselves in many dimensions in the world of globalization and information technology development. Through the "Action plan for fighting corruption and economic crime" (2022), IFAC has provided a framework for how to improve the role of the accounting profession in the fight against corruption, aiming for alignment with the UN SDGs. In this context, Albania has also undertaken its reforms in several areas, such as in the field of financial reporting, justice, etc., focusing on strengthening institutions, increasing public trust, and involving professionals with integrity and an elevated level of professionalism. Implications of the Research: Albania has been working for a long time now to align its legislation with that of the EU, in the framework of EU Integration. Among other areas, there have been a lot of developments toward the harmonization of the legal framework in the field of accounting and audit profession regulation. One of the crucial points in financial information publication is the process of preparation and auditing of financial statements. The legal framework altogether with the reporting standards should aim to encourage the publication of a true and fair view of financial information. It is recommended that the accounting professionals should show caution to prepare financial statements in accordance with national accounting standards, or international financial reporting standards evidencing the true and fair view of the entity's activity. Originality/Value: This paper presents the effect of financial reporting and criminal-juridical protection on the level of corruption in Albania. This goal is achieved by evidencing statistical data on economic entities operating in our country, describing an analysis of criminal-juridical protection provided for in the Criminal Code in force in the Republic of Albania, as well as based on a literature studied to understand how the financial reporting of entities is an important instrument for identifying corruption and what is foreseen in this criminal offense, as a means of preventing corruption and conducting business activity in accordance with legal acts.

Adaptation in the New Challenges of Globalization in Game and Animation Industry

During the Covid-19 pandemic, the absorption rate of alumni in the industry has decreased. Alumni who are already working, have independent studios, or work as freelancers are also impacted by the deteriorating economic conditions in Indonesia. Competition among graduates in the creative industry, including UM Animation Game D3 graduates, is intensifying, particularly in the local sphere. If not anticipated, many of them may face unemployment. Globalization and technological developments have enabled the game and animation industry to thrive during the pandemic. Therefore, the purpose of this community service activity is to organize a Sharing and Discussion event to provide a space for discussion for workers in the creative industries, especially in the field of Games and Animation who have been successful during the pandemic with UM Animation Game alumni. The methodology employed in this initiative involves sharing and discussion sessions to elicit insights from alumni and presenters. This study concludes that alumni who working as freelancers, studio owners, and industry employees face career constraints and a declining market during the pandemic. This is because they do not take advantage of globalization to increase career paths to capture a wider market. On the other hand, according to the presenters, to be able to take advantage of globalization, alumni should have a good portfolio and be presented professionally, be involved in international scale forums and activities, take advantage of international scale networking platforms, have a good attitude at work, have the commitment to continue to develop, and master the international language. Keywords: animation game alumni, globalization, animation game industry

Redox-neutral electrochemical decontamination of hypersaline wastewater with high technology readiness level.

Industrial hypersaline wastewaters contain diverse pollutants that harm the environment. Recovering clean water, alkali and acid from these wastewaters can promote circular economy and environmental protection. However, current electrochemical and advanced oxidation processes, which rely on hydroxyl radicals to degrade organic compounds, are inefficient and energy intensive. Here we report a flow-through redox-neutral electrochemical reactor (FRER) that effectively removes organic contaminants from hypersaline wastewaters via the chlorination-dehalogenation-hydroxylation route involving radical-radical cross-coupling. Bench-scale experiments demonstrate that the FRER achieves over 75% removal of total organic carbon across various compounds, and it maintains decontamination performance for over 360 h and continuously treats real hypersaline wastewaters for two months without corrosion. Integrating the FRER with electrodialysis reduces operating costs by 63.3% and CO2 emissions by 82.6% when compared with traditional multi-effect evaporation-crystallization techniques, placing our system at technology readiness levels of 7-8. The desalinated water, high-purity NaOH (>95%) and acid produced offset industrial production activities and thus support global sustainable development objectives.

Learning search algorithm: framework and comprehensive performance for solving optimization problems

In this study, the Learning Search Algorithm (LSA) is introduced as an innovative optimization algorithm that draws inspiration from swarm intelligence principles and mimics the social learning behavior observed in humans. The LSA algorithm optimizes the search process by integrating historical experience and real-time social information, enabling it to effectively navigate complex problem spaces. By doing so, it enhances its global development capability and provides efficient solutions to challenging optimization tasks. Additionally, the algorithm improves the collective learning capacity by incorporating teaching and active learning behaviors within the population, leading to improved local development capabilities. Furthermore, a dynamic adaptive control factor is utilized to regulate the algorithm’s global exploration and local development abilities. The proposed algorithm is rigorously evaluated using 40 benchmark test functions from IEEE CEC 2014 and CEC 2020, and compared against nine established evolutionary algorithms as well as 11 recently improved algorithms. The experimental results demonstrate the superiority of the LSA algorithm, as it achieves the top rank in the Friedman rank-sum test, highlighting its power and competitiveness. Moreover, the LSA algorithm is successfully applied to solve six real-world engineering problems and 15 UCI datasets of feature selection problems, showcasing its significant advantages and potential for practical applications in engineering problems and feature selection problems.

Renewable energy and sustainable development goals: Insights from latent dirichlet allocation thematic and bibliometric analysis

AbstractThis research conducts a comprehensive analysis of the intricate relationship between renewable energy and the sustainable development goals (SDGs). Employing diverse methodologies including latent dirichlet allocation (LDA) topic modeling, bibliometrics, citation analysis, and regression modeling, the study explores the evolving landscape of renewable energy research and its implications for SDGs. The analysis identifies a pronounced scholarly interest in renewable energy, reflected in the escalating publication volumes and citations across environmental sciences, green technology, and energy studies. Through meticulous examination, it uncovers interconnected research themes; encompassing policy uncertainty, Environmental Kuznets Curve, and ecological footprint, elucidating the multifaceted impact of renewable energy on the SDGs. Geographical distributions underscore diverse regional focuses, emphasizing the need for nuanced, context‐specific approaches. Regression analysis highlights influential factors like carbon dioxide emissions and gross domestic product (GDP) growth, delineating their pivotal roles in shaping scholarly attention toward renewable energy research. Furthermore, the study delves into the economic, environmental, and social dimensions of renewable energy's influence. It reveals its contributions to employment generation, sustainable production, energy access, and infrastructure development while navigating challenges related to climate change mitigation and biodiversity conservation. This comprehensive investigation offers crucial insights into the complex interplay between renewable energy and the SDGs. It predicts future research directions and highlights the urgency for interdisciplinary collaboration, international cooperation, and policy innovations to harness renewable energy's transformative potential for global sustainable development.

Application of the concepts of triple, quadruple and quintuple helices: a pilot project addressing the university-company relationship, innovation and entrepreneurship and the dissemination of technological knowledge

The importance of the university-company relationship has been growing in innovation studies, as the university is a great source of information for the innovative needs of companies. The objective of this work was to discuss the university-company relationship, considering the concepts of triple, quadruple and quintuple helix as factors that promote innovation. The methodology used was based on a systematic literature review, which presents a synthesis of the multiple articles evaluated and used. The evaluated results made it possible to highlight numerous advantages, barriers, facilitators and aspects that stimulate this relationship. Furthermore, it was possible to see how innovation, entrepreneurship and technological knowledge are important in the university-company relationship, showing that there is a need to stimulate this relationship with the aim of reducing the relationship barriers identified, as, in the current context of globalization and high-level technology development, this cooperation is of great importance for the country, positively influencing technological advances.

Toward Sustainable Global Product Development Performance: Exploring the Criticality of Organizational Factors and the Moderating Influence of Global Innovation Culture

In today’s dynamic and global landscape, innovation and globalization are intricately linked drivers that propel modern businesses forward, serving as indispensable pillars upon which organizations heavily rely to maintain their competitive edge. Leveraging innovation within the context of global product development (GPD) practices is imperative for organizations seeking to survive and effectively compete in the rapidly evolving marketplace. While preceding studies have primarily focused on the importance of individual and organizational capabilities, policies, and cultural factors in driving product development (PD) performance, they often overlook their interconnectedness within a global context. To address this gap, this study delves into the relationship between organizational factors and global product development performance (GPDP) while examining the moderating influence of global innovation culture (GIC). These organizational factors encompass technological innovation capabilities (TICs), team creativity (TC), dynamic capabilities (DCA), and competitive advantage (CA). Our hypothesis suggests a positive impact of these factors on GPD performance. Employing a structural equation modeling (SEM) approach through SMART-PLS 3, we analyzed data collected from 480 questionnaire forms distributed among registered global product development (GPD) organizations operating in China. The empirical findings underscore the significant influence of organizational factors on GPD performance, highlighting the critical role of global innovation culture in shaping these relationships. These insights shed light on the importance of establishing a harmonious balance between organizational culture and various factors to enhance interaction among organizational elements and optimize global product development performance. Ultimately, these efforts can lead to improvements in the overall effectiveness and sustained global product development.

Innovative Methodologies of Active Learning to Develop the Competencies of the Future of Work

International organizations promoting economic growth and global development are increasingly requesting higher education systems to prepare students with the fundamental attitude and skills to be competitive in the future workplace. After conducting two separate literature reviews on active learning strategies and on the most demanded competencies in the future of work, the paper proposes a comprehensive framework of 31 competencies pivotal for future professionals to thrive in an innovative work landscape. In the effort to nurture these skills, it further explores the contributions of the most popular active learning methodologies and delves into the role of digital technologies in enhancing the learning experience. Significantly, the paper reveals that active learning not only develops technical and methodological competencies but also enriches social, personal, and particularly digital skills, positioning students to effectively navigate and contribute to the digital economy. The emergent pedagogies underscore the importance of fostering lifelong learning, self-agency, and the adept use of diverse tools and resources, essential for the professionals of today and tomorrow.

Global development in the Arctic: international cooperation for the future

Global development in the Arctic: international cooperation for the future

IoT Based Smart Helmet for Industry Rutuja Kokate

The safety and well-being of industrial workers has become a primary concern for organizations worldwide. One of the critical aspects of industrial safety is the use of personal protective equipment (PPE), including helmets. This project proposes the development of an IoT-based smart helmet designed to enhance the safety and efficiency of industrial workers. The smart helmet integrates multiple sensors, such as temperature, humidity, motion, and gas sensors, to monitor the worker's environment in real-time. These sensors gather data on potential hazards like extreme temperatures, toxic gases, or sudden impacts. The helmet also includes a communication system that enables seamless interaction with control centers or other team members. The mining industry, a vital contributor to global economic growth and infrastructure development, grapples with inherent safety challenges posed by hazardous environments and unpredictable events. In response to these concerns, this abstract introduces the "Smart Helmet for Air Quality and Hazardous Event Detection" – a groundbreaking technology tailored specifically for mining. This advanced helmet integrates sensors like the MQ3 gas sensor, temperature and humidity sensors, LED lights with automatic controls, and a GPS module. Real-time data from these sensors are transmitted to an IoT platform, enabling continuous monitoring and immediate alerts. Traditional safety measures, including personal protective equipment and periodic monitoring, fall short in addressing the dynamic conditions of mining environments. The Smart Helmet offers a comprehensive solution by providing continuous air quality and environmental monitoring, coupled with automatic lighting and location tracking. This innovation marks a paradigm shift in mining safety, addressing the urgent need for proactive measures to safeguard the well-being of miners in the face of persistent safety challenges. Key Words: Safety, Sensors, IoT, Smart Helmet, Air quality monitoring

Evaluation of the cooling flow rate of the cooled steam turbine for a novel H<sub>2</sub>/O<sub>2</sub> cycle

Evaluation of the cooling flow rate of the cooled steam turbine for a novel H<sub>2</sub>/O<sub>2</sub> cycle